Publications

Citations: 1493 (Google Scholar, 2024 March)
(co)first and / or corresponding author | coauthor | collaborator or consortium authorship

Preprints

• The EFFECT benchmark suite: measuring cancer sensitivity prediction performance - without the bias bioRxiv 2023
• Receptor endocytosis orchestrates the spatiotemporal bias of β-arrestin signaling - bioRxiv 2023

Mechanistic inisight from omics data

• Application of perturbation gene expression profiles in drug discovery—From mechanism of action to quantitative modelling - Frontiers in Systems Biology 2023
• Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data - Nature Communications 2022
• Modeling in systems biology: Causal understanding before prediction? - Patterns 2021
• Why do pathway methods work better than they should? - FEBS Letters 2020
• Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data - Genome Biology 2020
• Transfer of regulatory knowledge from human to mouse for functional genomic analysis - BBA - Gene Regulatory Mechanisms 2020

Pharmacogenomics of cancer

• Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets Nature Communications 2022
• Patient-specific Boolean models of signaling networks guide personalized treatments - eLife 2022
• A community challenge for a pancancer drug mechanism of action inference from perturbational profile data - Cell Reports Medicine 2022
• Signatures of cell death and proliferation in perturbation transcriptomics data - from confounding factor to effective prediction - Nucleic Acids Research 2019
• Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen - Nature Communications 2019
• A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines - Cell Systems 2017

Other cancer research

• Inferring clonal composition from multiple tumor biopsies - npj systems biology and applications 2020

SARS-CoV-2

• Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity - PLoS Computational Biology 2022

Chemoinformatics

• Crowdsourced mapping of unexplored target space of kinase inhibitors - Nature Communications 2021
• Predicting human olfactory perception from chemical features of odor molecules - Science 2017

Signaling and dimerization G-protein coupled receptors

(mostly related to my PhD project)

• Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3 - iScience 2023
• An Unexpected Enzyme in Vascular Smooth Muscle Cells: Angiotensin II Upregulates Cholesterol-25-Hydroxylase Gene Expression - IJMS 2023
• Characterization of Type 1 Angiotensin II Receptor Activation Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes in Rat Vascular Smooth Muscle Cells - cells 2021
• Angiotensin type 1A receptor regulates β-arrestin binding of the β2-adrenergic receptor via heterodimerization - Molecular and Cellular Endocrinology 2017
• Improved methodical approach for quantitative BRET analysis of G Protein Coupled Receptor dimerization - PLoS One 2014
• Allosteric interactions within the AT1 angiotensin receptor homodimer: role of the conserved DRY motif - Biochemical Pharmacology 2012
• Mechanisms of angiotensin II-mediated regulation of aldosterone synthase expression in H295R human adrenocortical and rat adrenal glomerulosa cells - Molecular and Cellular Endocrinology 2008